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A thiazide diuretic of the average intensity, applied in arterial hypertension, edema syndrome of different origin, gestosis and diabetes insipidus. Reduces reabsorption of Na+ at the level of the Henle loop cortical segment, without affecting its segment lying in the medulla of the kidney that detects a weaker diuretic effect compared with furosemide.

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10mg enalapril cost -effectiveness for the prevention of major cardiovascular events. METHODS: A systematic review was performed to determine whether there is a difference in the rate of serious cardiovascular events between those undergoing enalapril or placebo for the antihypertensive effect in hypertensive patients with acute ischemic stroke or neuropathy. RESULTS: Four cohort studies were identified that reported the number of stroke or neuropathy events in subjects receiving either enalapril 30 mg or 20mg placebo for the prevention of CHD events. A combined analysis of these 4 cohort studies demonstrated that there was no significant difference in cardiovascular outcomes patients treated with 30mg or 20mg for the prevention of CHD events (total cardiovascular mortality 4.6% (95% CI 0.7-12.8, P=-0.03); death by cardiovascular cause 6.8% (95% CI 0.4-31.7, P=0.7); stroke 15.1% (1.6-78.4, P=0.08); and MI 23.9% (3.8-83.0, P=0.001)). Additionally, a meta-analysis of all RCT and randomized control trials reporting the total benefit in patients with moderate to severe CHD events (n=3,100) revealed no difference in overall survival, the composite outcomes of stroke, death by cardiovascular cause, or major bleeding (HR=0.93, 95% CI 0.87-0.97, P = 0.9); all other effects remained in the null (RR=1.04 (95% CI 0.98-1.11), Reglan otc substitute P=-0.09). Finally, a pooled analysis of all RCT trials evaluating the effect of 20mg or 30mg in the prevention of CHD events did not reveal significant difference between the 20-mg and placebo groups (RR=0.94, 95% CI 0.88-0.98, P=0.9); in fact, the rate reductions of CHD events were less than the placebo rate reductions (p=0.08-0.3) which could be interpreted either as being no difference in CHD event rates between the placebo and 20-mg groups or as lower rate of adverse events observed in the active treatment group than in A thiazide diuretic of the average intensity, applied in arterial hypertension, edema syndrome of different origin, gestosis and diabetes insipidus. Reduces reabsorption of Na+ at the level of the Henle loop cortical segment, without affecting its segment lying in the medulla of the kidney that detects a weaker diuretic effect compared with furosemide. the placebo group. Lastly, a meta-analysis of all RCTs the antihypertensive effect on ischemic stroke indicated that, in a population of subjects with stroke, treated enalapril for 6 months experienced a significantly higher rate of ischemic stroke (2.7/100 person-years versus 0.8/100 person-years, p=1.0 x 10(-8)). CONCLUSION: The results of this systematic review show that enalapril and 30 mg have similar antihypertensive benefits in the prevention of major cardiovascular events, but the difference in efficacy between respective compounds was not significant.

A thiazide diuretic of the average intensity, applied in arterial hypertension, edema syndrome of different origin, gestosis and diabetes insipidus. Reduces reabsorption of Na+ at the level of the Henle loop cortical segment, without affecting its segment lying in the medulla of the kidney that detects a weaker diuretic effect compared with furosemide.

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